Study Design and Statistical Evaluation of QT Prolongation

Medicines and QT Prolongation

Antipsychotic Medication and QT Prolongation

The QT interval represents ventricular depolarisation and repolarisation. Prolongation of this interval can lead to life-threatening complications. These can include arrhythmias such as Torsades de Pointes and Ventricular Fibrillation, which may ultimately lead to death. Many risk factors have been identified in prolonging the QT interval, one of which is medication commonly used in the treatme...

Drug induced QT prolongation.

The drug-induced QT prolongation predisposes to development of torsades de pointes (TdP) ventricular tachycardia and sudden death. The association between specific drug and development of TdP is difficult to document, therefore, QT prolongation is considered as a surrogate marker of the proarrhythmia risk. Most of the drugs prolong QT interval usually by blocking the potassium IKr current or al...

Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram.

BACKGROUND Although QT prolongation is associated with increased risk of torsade de pointes (TdP), the precise relationship is not well defined. AIM To evaluate the performance of a QT nomogram in assessing the risk of TdP from QT-RR combinations. DESIGN Systematic review. METHODS We systematically searched MEDLINE/EMBASE for cases of drug-induced TdP. Controls were patients taking non-ca...

a study on the design of bio-ethanol process from date wastes of sistan and baluchistan province

اتانول کاربردهای متنوعی در صنایع لاستیک سازی، رنگسازی، حلالها ومکمل سوخت خودرو دارد. اتانول برخلاف نفت از جمله مواد تجدیدپذیر محسوب می شود که مشکلات زیست محیطی و آلودگی نیز ایجاد نمی کند. استفاده از اتانول به عنوان مکمل سوختخودروها از جمله مهمترین مصارف صنعتی این ماده بشمار می رود. با توجه به این موضوع تحقیق و توسعه در زمینه تولید اتانول با درجه خلوص بالا در سطح جهان، و نه تنها در کشور های پیشر...